Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains
نویسندگان
چکیده
منابع مشابه
Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains.
Common inbred strains of the laboratory rat can be divided into four different mitochondrial DNA haplotype groups represented by the SHR, BN, LEW, and F344 strains. In the current study, we investigated the metabolic and hemodynamic effects of the SHR vs. LEW mitochondrial genomes by comparing the SHR to a new SHR conplastic strain, SHR-mt(LEW); these strains are genetically identical except fo...
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Tibetan yak (Bos grunniens) inhabiting the Qinghai-Tibet Plateau (QTP) where the average altitude is 4000 m, is specially adapted to live at these altitudes. Conversely, cattle (B. taurus) has been found to suffer from high-altitude hypertension or heart failure when exposed to these high altitudes. Two mitochondrial genes, MT-ND1 and MT-ND2, encode two subunits of NADH dehydrogenase play an es...
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In this research we have studied the effects of extremely low frequency magnetic field on the peripheral blood lymphocytes chromosomes of human in vitro and rat in vivo. By this means, we used 60 blood samples of 10 men as well as 40 rats. Of 60 human blood samples ,40 samples (in two group of 20) were selected as test groups and placed into the 2 mT and 35 Hz magnetic field. The blood samples,...
متن کاملشناسایی، همسانه سازی وتعیین توالی ژن MT ND2 در مرغ‌های بومی خراسان
میتوکندری مسئول تولید 90 درصد از انرژی مورد نیاز سلول می باشد. مقداری از تفاوت‌ها در عملکرد رشد جوجه‌های گوشتی و بیان فنوتیپی راندمان غذایی ممکن است مربوط به اختلاف در راندمان عملکرد میتوکندری باشد. این پژوهش بمنظور همسانه سازی و تحلیل مرغان بومی خراسان با تاکید بر ژن ND2 به منظور بررسی جهشهای احتمالی است. بدین منظور از نمونه خون مرغ بومی خراسان، DNA ژنومی استخراج گردید و با استفاده از آغازگ...
متن کاملIsolation and identification of metallothionein isoforms (MT-1 and MT-2) in the rat testis.
It has been a long-lasting controversial issue as to whether or not the male genital organs, such as the testis and prostate, contain metallothioneins (MTs), a group of cysteine-rich heavy-metal-binding proteins that play a role in detoxifying heavy metals such as cadmium (Cd). Earlier studies reported that the rodent testis lacks MTs and concluded that this is why the testis is very susceptibl...
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ژورنال
عنوان ژورنال: Physiological Genomics
سال: 2012
ISSN: 1094-8341,1531-2267
DOI: 10.1152/physiolgenomics.00156.2011